Kannrybio | Implant-grade Bioactive Ceramics & Calcium Phosphate Powders

Calcium phosphate bone cement (CPC): picking the reactive pair and the setting window

A practical guide to α‑TCP/TTCP/DCPA/DCPD choices, setting time targets, and the spec lines that prevent qualification rework.

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Most CPC failures in early qualification have nothing to do with “purity”. They come from a missing definition of reactive pair, PSD window, and setting profile. This page gives you a simple, OEM‑friendly way to specify CPC powders so your pilot batch behaves like your scale batch.

Where CPC performance comes from

  • Reactive pair: common systems include α‑TCP + TTCP, or α‑TCP + DCPA/DCPD blends.
  • PSD & surface area: finer powders accelerate setting but raise water demand and shrink the workable window.
  • Liquid phase: phosphate buffers, ions, and additives change kinetics as much as the powder does.

Recommended Kannry product options

Use caseRecommended materialsNotes
Fast setting, high early strengthα‑TCP + TTCPTypical for orthopedic CPC; tune PSD to hit target setting time.
Moderate setting, smoother injectabilityα‑TCP + DCPA (or DCPD)Often used to control kinetics and rheology.
Turn‑key qualification startCPC Powder KitConvenient for feasibility work; spec finalized during scale‑up.

A spec template that survives scale‑up

Copy/paste this into your RFQ and fill the blanks:

Powder system: α‑TCP + TTCP (or α‑TCP + DCPA/DCPD)
PSD: D10–D90 window (method stated: laser diffraction / dispersion protocol)
BET: target range (m²/g) + method
Phase: α/β ratio or phase purity requirement (XRD)
Impurities: total heavy metals limit + key ions if required
Setting: initial / final setting time targets (test method, temp, L/P ratio)
Packaging: 100 g / 1 kg / 5 kg; moisture control; desiccant

Common failure modes

  • Comparing PSD from different dispersion methods (DLS vs laser diffraction vs SEM image analysis).
  • Over‑tight BET range without tying it to setting time measurement.
  • Changing milling step during scale‑up and unintentionally shifting hydration kinetics.
Fast track: If you send your target setting profile and injectability requirement, we can recommend a starting PSD/BET window and documentation scope.

Contact us for grade recommendation