45S5 composition & performance: what matters in real devices

45S5 is often described as a single composition—but production lots can behave differently if composition control, thermal history, and morphology drift. The goal is not chasing a perfect number; it’s writing a spec that keeps reactivity and processing behavior stable across scale and time.

For 45S5, the same nominal composition can show different reactivity depending on processing history and morphology. If your program is sensitive to dissolution/reactivity, pair composition control with at least one process-relevant check (and define the acceptable variability).

Composition windows vs ‘exact’ values

• 45S5 is commonly expressed as 45/24.5/24.5/6 wt% (SiO₂/CaO/Na₂O/P₂O₅).
• Small drifts can matter depending on your device concept—align acceptable windows to your risk assessment.
• If you need tight behavior, specify both composition and a functional proxy (e.g., dissolution or a process-relevant test).

Tip: if you’re unsure which bullet is critical, tell us your process step that fails (feeding, mixing, viscosity, setting). We’ll map the failure mode to the right spec controls.

Thermal history: the quiet variable

• Melting/cooling and subsequent heat exposure can affect structure and reactivity.
• Batch-to-batch changes may show up as processing differences before they show up as simple composition numbers.

Tip: if you’re unsure which bullet is critical, tell us your process step that fails (feeding, mixing, viscosity, setting). We’ll map the failure mode to the right spec controls.

Morphology & PSD: why microspheres differ from powder

• Microspheres feed and pack differently than irregular powders; that often matters more than chemistry.
• PSD method and fines content can dominate flow, blending, and packing behavior.

Tip: if you’re unsure which bullet is critical, tell us your process step that fails (feeding, mixing, viscosity, setting). We’ll map the failure mode to the right spec controls.

What to write in a practical 45S5 spec

Rule of thumb: if a parameter affects your process, include the method and sample prep in the spec. That single line saves weeks later.

Sampling checklist

• Confirm the form factor (micro powder vs microspheres vs nano) that matches your workflow.
• Define PSD method and acceptable fines content if flow matters.
• State packaging + moisture protection expectations.

Tip: if you’re unsure which bullet is critical, tell us your process step that fails (feeding, mixing, viscosity, setting). We’ll map the failure mode to the right spec controls.

Example spec snippet (copy/paste)

• Product: [phase/form factor]
• Particle size (PSD): [range] — Method: [laser diffraction / sieve / DLS], dispersion: [settings]
• Moisture: ≤ [x]% — Packaging: sealed, moisture-protected
• Documentation: Typical values for evaluation; Full COA for production lots on request
• Lot-to-lot variability: [acceptable ranges] for PSD/moisture/other critical items

Talk to us

Email info@kannrybio.com or use the contact form to discuss your target spec and stage (evaluation vs production). We can recommend a suitable grade and documentation scope.